Kansas Jayhawks vs. Iowa State betting, spread, prop bets, over/under, prediction

Iowa State vs. Kansas Jayhawks betting/spread

On DraftKings Sportsbook, Kansas football is a 2.5-point underdog to Iowa State. You can take KU's odds at -112 or Iowa State's at -108. The Cyclones are -130 moneyline favorites, while the Jayhawks' moneyline sits at +110. FanDuel Sportsbook has the same 2.5-point spread and a slightly different moneyline, favoring Iowa State at -128.

Iowa State vs. Kansas Jayhawks prop bets

There are several prop bets to choose from on DraftKings. We will list the ones we believe are best to put money on. Iowa State is one of the best defensive teams in the country, but they also struggle offensively at times. Expect the Cyclones to force KU to make early mistakes and chip away offensively. Pair any of these prop bets for a shot to win big on your parlay.

Jayden Higgins 81+ receiving yards 
Jalon Daniels 2+ passing TDs
Devin Neal 90+ rushing yards
Luke Grimm 50+ receiving yards 
OVER 6 total touchdowns scored

Iowa State vs. Kansas Jayhawks over/under

The over/under on the contest is 51 points. The Jayhawks have surpassed that total five times in their eight games this year with one push. While their games have reached that mark in each conference game, the Cyclones have a much better defense than any team KU has faced. ISU's games have reached the 51-point mark only three times in 2024.

Iowa State vs. Kansas Jayhawks prediction

Iowa State’s season took a tough turn with a last-second loss to Texas Tech after leading with just over 20 seconds remaining. Their strong defense, ranked ninth nationally and allowing only 15.5 points per game, has been the key to success despite a modest offense. The Cyclones now aim to bounce back and keep their College Football Playoff hopes alive.

Kansas has suffered crushing fourth-quarter losses in five of its six defeats this season, slipping through the fingers of Lance Leipold and Co. time and time again. The Jayhawks can only hope to play spoiler against Iowa State. While there have been flashes in recent weeks and KU is well-rested off the bye, ISU will be hungry for a victory after last week and is a much better-coached football team.

Final Prediction: 31-21, Iowa State (Covers -2.5)